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  • Cialis vs Its Cheaper Analogue Apcalis SX: Is It as Effective?

    Cialis’s Generics

    Cialis’s active substance is tadalafil. One of the most popular trademarks of generic form of Cialis is Apcalis SX. All Cialis generics are produced by famous pharmaceutical companies and give absolutely similar effect but at a cheaper price.

    But before you choose Cialis or its analogues, you should state a reason of your functional disorders in order to avoid two misconceptions:

    • Cialis and its generics are not sexual stimulants in a sense people understand it at a simple level. This class of medicines does not cause erection automatically regardless of presence or absence of sexual excitement. The action of the medicine is manifested in its capacity to provide sufficient blood supply to penis and only along with sexual stimulation.
    • Cialis and its generics are not able to treat erectile dysfunction if they are caused by physiological deformations of penis, etc. These medicines are quite helpful in treatment of mainly psychological condition, when a man loses his self-confidence because of one failure. Non-confidence makes problems of functional character especially inability to preserve steady erection within a long period of time. Tadalafil is exactly the remedy able to solve this issue.

    Tadalafil-Containing Medicines

    Tadalafil-Containing MedicinesCialis and its generics contain tadalafil. The active component of the drug inhibits phosphodiesterase type 5 selectively. During sexual stimulation, nitrogen oxide is locally released, while inhibition of phosphodiesterase type 5 leads to increase of cyclic guanosine monophosphate in cavernous bodies. Under tadalafil’s action there is a decrease of unstriated muscles tonus which contributes to improvement of erection. Tadalafil doesn’t cause sexual stimulation. Its action on other types of phosphodiesterase is insignificant; therefore, Cialis doesn’t influence cardio-vascular system, hepatic function, skeletal muscles and other organs. Tadalafil doesn’t change qualitative characteristics of semen and doesn’t change testosterone level, follicle-stimulating and luteinizing hormones in blood. The effect of Cialis and Apcalis SX develops only with availability of sexual stimulation. The beginning of therapeutic effect occurs in 15 minutes after the intake and lasts within 36 hours after peroral use.

    Tadalafil is generally metabolized with participation of isoenzyme CYP3 A4 of cytochrome P450. The main circulating metabolite is methyl catechol glucoronide. This metabolite is as 13000 times as less active in regards to PDE5 than tadalafil. Thus, concentration of this metabolite is not clinically significant.

    Healthy men have average level of clearance equal to 2,5l/hour. Tadalafil is cleared in form of inactive metabolites mainly with feces (around 61% of a dose) and to a lesser degree with urine (around 36% of a dose).

    Tadalafil Application

    Cialis and its generics are applied to treatment of erectile disorders of physiological and psychological origin as well as for the purpose of sexual intercourse quality boost. They are used perorally. Cialis and Apcalis SX are represented in the form of a tablet with coating and jelly. These medicines are taken regardless of food acceptance. Usually they are prescribed to be taken 15-30 minutes before planned sexual intercourse. The effect keeps within 36 hours.

    Apcalis SX Description

    Apcalis SX DescriptionApcalis SX is the one-of-a-kind Cialis analogue in jelly form which is manufactured by pharmaceutical Indian company Ajanta Pharma Ltd. Its action is identical to Cialis according to its action, but their costs are out of proportion. It is issued in the form of jelly. The remedy is issued in sachets. Each of the sachets contains 5 grams of gelatinous substance which includes 20mg of tadalafil. Jelly is represented by five difference flavor additives: banana, orange, etc. Jelly taste has no influence on medicine. According to its chemical composition, Apcalis SX is an absolute chemical analogue of reputable Cialis (tadalafil) which is a selective phosphodiesterase type 5 inhibitor. It is used for elimination of male sexual disorders, such as erectile dysfunction and difficulty to keep erected condition of penis. As a result of the intake of one therapeutic dose (20mg) there is a relaxation of unstriated muscles of penis cavernous bodies and active blood filling leading to a steady erection sufficient for fully-realized sexual intercourse.

    Apcalis SX is taken not less than 15 minutes before planned sexual intercourse. A sachet should be opened pressing its contents out directly into mouth cavity. Jelly should not be swallowed immediately – you need to wait until jelly gets dissolved in mouth. Within minimal action period of 36 hours, a man will take pleasure of Apcalis excellent effect. Maximal daily dosage is 20mg per day.

    Therefore, if a man has erectile dysfunction, Apcalis SX is worth purchasing but on doctor’s orders. On the other hand, one should not rely completely on the time within which the medicine in organism is completely active. The remedy’s description reads 15 minutes. This may be correspondent to reality in a specific case. First of all, the time is influenced by age and testosterone level in blood which are essential for libido (sexual attraction).

    According to the instruction, average maximal concentration of Apcalis SX in blood (Cmax) for tadalafil is achieved in 2 hours after the intake of a pill. Therefore, one should not wait for instant action, but in 1-1,5 hours the effect will be absolutely perfect.

    This medication takes its action only with sexual stimulation relaxing penis blood vessels and contributing to enhanced blood supply for strong erection. This medication help to achieve a steady natural potency only in case of psychological or age causes of erectile dysfunction. If problems are connected with other diseases, the remedy won’t be helpful.

    Apcalis SX Advantages and Efficiency

    According to numerous reviews, gelatinous form of Apcalis SX takes much faster effect in comparison with other tadalafil-containing drugs for ED and causes less side-effects. In comparison with other medicines, such as Super Tadarise Apcalis SX has a much longer action period lasting 36-40 hours during which a man is able to have as many sexual intercourses as he wants to.  It should be noted that the time indicated in the instruction is underrated. According to the reviews, the intake of one 20mg pill allows a man to be in a perfect shape much longer. In most cases Apcalis action lasts 72 hours and there is more to come.

    Many people ask what a new generation generic means and why it costs much cheaper than a traditional medicine. The active substance of both drugs is tadalafil, but Indian pharmaceutical company producing Apcalis SX hasn’t spent much money on research studies, long-term elaboration of a manufacturing process, clinical trials, but simply acquired the patent. Therefore, the company sells the remedy at a quite reasonable price.

    Apcalis SX Counterindications

    The remedy is mot prescribed in the following cases:

    • If a patient is hypersensitive to tadalafil;
    • In case a patient takes organic nitrates;
    • Apcalis SX is not administered by women and children under 18 years of age.
    • The medication is not recommended for patients with cardio-vascular diseases including those who are contraindicative to sexual activity;
    • If a patient has undergone heart or apoplectic attack within the last six months;
    • Apcalis SX is not to be taken by those who suffer from cardiac failure of the second stage, unstable angina, uncontrolled arrhythmia or hypertension, pronounced arterial hypertension.

    Apcalis SX should be taken with care by patients with underlying risk of priapism development, leukemia, sickle-cell anemia, erythroid myeloma, penis angulation, cavernosal fibrosis, and Peyronie’s disease. Moreover, patients should be careful while taking tadalafil if they suffer from renal or hepatic disorders and those who administer alpha-adrenergic blocking agents.

    Apcalis SX Side-Effects

    One of the most undesired effects are headache and dyspepsia (11 and 7% cases accordingly). Side-effects connected with tadalafil intake are of insignificant or moderate character. They are temporary and disappear with the continuance of drug administration. Other undesirable effects are backache, myalgia, stuffiness in nose, blushing. Very seldom a patient may experience hypersensitivity reactions including rash, urticaria, facial oedema, Stevens–Johnson syndrome, exfoliative dermatitis; hypertension and syncope; stomachache and esophageal reflux; hyperhidrosis; priapism and erection detain; blurred vision; non-arterial anteriorischemic optic neuropathy; retinal vein occlusion; sight disturbance.