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  • Sildenafil Citrate in Erectile Dysfunction Treatment

    Sildenafil Citrate does all the work when it comes to ED treatment. Viagra’s main ingredient proved its efficacy, but its benefits prevail over drawbacks only, if you know how to take it. Do you?

    The Active Ingredient of Generic Viagra Sildenafil CitrateWhat is Sildenafil Citrate? It is a white crystalline powder with a solubility of 3.5 mg/mL in water. Blue and film-coated Viagra pills are equivalent to 25, 50 and 100 mg of Sildenafil Citrate. However, aside of the main ingredient, Generic Viagra contains some secondary ones, but first things first.

    Label and Investigational Uses of Sildenafil Citrate

    • Label Use

    Sildenafil treats erectile dysfunction issue in males, their inability either to achieve or maintain an erection that is hard enough for an adequate sexual intercourse. It is reported that around 15 million males in the USA suffer from impotence. By the age of 65 most of them had experienced the first problems.

    Frankly speaking, the condition of erectile dysfunction is triggered by different psychological and physiological problems. Among a variety of possible triggers, doctors define several common ones:

    1. Prostate cancer;
    2. Depression;
    3. Multiple sclerosis;
    4. Diabetes;
    5. Heart diseases;
    6. Arthrosclerosis.

    Some other causes are injuries to the penis. They lead to the damage of tissue, nerve and blood vessels. The condition may be a result of use of different medications like antidepressants and antihistamines, antipsychotics and antihypertensives, appetite suppressants and diuretics, beta blockers and tranquilizers.

    Whatever the trigger is, Sildenafil Citrate is able to cope with the issue in the fastest and safest way ever. It is equally effective and safe across ethnic and racial groups all over the world.

    • Investigational uses

    Sildenafil Citrate is not approved for use in females, yet the clinical studies showed that this chemical may have positive effects in cases of sexual dysfunction in females. There was a study with both males and females as participants. They all suffered from ED (males) and sexual dysfunction (females) and their conditions were related to the use of psychotropic meds. The participants reported an increase in the overall sexual satisfaction in general and arousal in particular, when they began taking Sildenafil Citrate. Some studies showed that this chemical may be effective in improving arousal and libido in women administering SSRIs.

    One more investigational use in women is infertility treatment. Some women with IVF failures because of the poor tissue development benefited from the treatment course with Sildenafil-containing vaginal suppositories. Label and Investigational Uses of Sildenafil Citrate

    In 2000 Johns Hopkins University School of Medicine in Baltimore conducted another study that proved Sildenafil Citrate to have additional clinical promises for patients with diabetes and ED. Conducted animal studies showed that the chemical is able to:

    • Relax the pyloric muscle of the stomach;
    • Improve digestion;
    • Relieve symptoms of gastro paresis.

    It is true that nearly 75% of diabetics have a gastro paresis condition that leads to nausea and bloating, vomiting and appetite loss. Though the researches gave obvious evidence, additional human studies are needed.

    Sildenafil citrate has the capacity to enhance the production of nitric oxide. And this is why it is investigated as the treatment for disorders triggered by the impaired production of nitric oxide. Achalasia is one of such disorders. It’s the esophageal motility dysfunction in which the esophagus’ smooth muscles and the cardiac sphincter are constricted. This leads to the difficulties in food regulation, swallowing and chest pain when eating.

    In 2002 it was proven that Sildenafil citrate can improve the condition adding to the muscle relaxation. In 2002 the chemical showed promises as an effective treatment for spastic esophageal disorders.

    Pharmacokinetics and Metabolism of Sildenafil Citrate

    Sildenafil Citrate is quickly absorbed after oral administration. The mean absolute bioavailability is 41% (range 25-63%). The pharmacokinetics is dose proportional over the suggested dose range. The chemical is eliminated by hepatic metabolism and is converted to an active metabolite. Sildenafil and the metabolite have half lives of about four hours.

    Sildenafil Citrate Interacts with Other Meds

    Sildenafil Citrate is known for interacting with herbs, vitamins and other meds. An interaction leads to changes in the way the drug works. It may be very harmful at times and lead to hospitalization or even death. In order to avoid dangerous interactions, inform your physician of all the medications that you take.

    There are two types of drugs that may interact with Sildenafil Citrate and lead to really harmful adverse reactions:

    • Guanylate cyclase stimulators (Riociguat, for example): the combination leads to the low blood pressure;
    • Nitrates (isosorbide dinitrate, isosorbide mononitrate and nitroglycerin): the combination leads to the low blood pressure.Viagra pills

    It is know that there are also interactions that can increase the risks for side effects from Sildenafil Citrate as the amount of this chemical grows:

    • Antibiotics (Erythromycin, Clarithromycin and Telithromycin): the combination leads to vision problems, low blood pressure and dizziness. At times there are priapism cases (erections last longer and become very painful);
    • HIV drugs – human immunodeficiency virus drugs – (Indinavir, Ritonavir, Atazanavir and Saquinavir: the combination leads to vision problems, low blood pressure and dizziness. At times there are priapism cases (erections last longer and become very painful);
    • Antifungals (Itraconazole and Ketoconazole): the combination leads to vision problems, low blood pressure and dizziness. At times there are priapism cases (erections last longer and become very painful);
    • Blood pressure meds (Amlodipine): the combination leads to the increased side effects and low blood pressure;
    • Alpha-blockers (Alfuzosin, Terazosin, Silodosin, Doxazosin and Tamsulosin): the combination leads to fainting;
    • ED drugs (Vardenafil and Tadalafil): the combination leads to priapism.

    ! It is suggested not to combine Sildenafil Citrate with alcohol. Alcoholic drinks raise risks of low blood pressure. Small amounts of red wine are allowed, but too much alcohol leads to serious health issues.

    Generic Viagra: Main and Secondary Ingredients

    Now you know much about the main ingredient of generic Viagra – Sildenafil Citrate. And what about its secondary ingredients that are inactive? They are called excipients that are added to mediations in order to support the effectiveness and aid with the ease of use. No side effects are caused by inactive ingredients.

    Generic Viagra also includes:

    1. Anhydrous dibasic calcium phosphate;Generic-Viagra
    2. Hypromellose;
    3. Microcrystalline cellulose;
    4. Triacetin;
    5. Croscarmellose sodium;
    6. Lactose;
    7. Magnesium stearate;
    8. Titanium dioxide.

    There are also coloring ingredients. According to FDA, they are safe when correctly used.

    Sildenafil Citrate proved its efficacy and reliability when used in Viagra for ED treatment. We insist on professional consultation before you actually buy the medication. It will allow you forget about possible complications and side effects.